Brouwer DA, van Beek J, Ferwerda H, Brugman AM, van der Klis FR, van der Heiden HJ, Muskiet FA (June 1998). "Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose". The British Journal of Nutrition. 79 (6): 527–532. doi: 10.1079/BJN19980091. PMID 9771340. We investigated the effect of oral high-dose cholecalciferol on plasma and adipose tissue cholecalciferol and its subsequent release, and on plasma 25-hydroxyvitamin D (25(OH)D). ... We conclude that orally-administered cholecalciferol rapidly accumulates in adipose tissue and that it is very slowly released while there is energy balance. Liquid products, chewable tablets, or dissolving tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely. a b "Aviticol 1 000 IU Capsules - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 30 December 2016 . Retrieved 29 December 2016. In general, no good evidence supports the commonly held belief that vitamin D supplements can help prevent osteoporosis. [13] Its general use for prevention of this disease in those without vitamin D deficiency is thus likely not needed. [12] For older people with osteoporosis, taking vitamin D with calcium may help prevent hip fractures, but it also slightly increases the risk of stomach and kidney problems. [64] A study found that supplementation with 800IU or more daily, in those older than 65 years was "somewhat favorable in the prevention of hip fracture and non-vertebral fracture". [65] The effect is small or none for people living independently. [66] [67] Low serum vitamin D levels have been associated with falls, and low bone mineral density. [68] Taking extra vitamin D, however, does not appear to change the risk. [69] Fortified Cereal: Making the right breakfast choices in the morning can have a tremendous affect on your health, particularly in terms of fortifying your body with enough vitamin D. Such cereals such as Multi-grain cereals are rich in vitamin D. Not to mention the added boost of vitamin D you get when eating it with fortified milk.

Because Vitamin D and calcium are related too much Vitamin D can lead to Calcium issues. These issues include, Hypercalcemia, Kidney Stones and Kidney damage. Colecalciferol comes as chewable, dissolvable (soluble) and melt-in-the-mouth (orodispersible) tablets, capsules, a syrup, and oral drops. Vitamin D is found in two different forms; ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), each of which differs slightly in terms of chemical structure. “Vitamin D3 is obtained from animal sources, whereas vitamin D2 is mainly from fungal sources,” explains John White, Ph.D., chair of the department of physiology at McGill University in Montreal and a molecular biologist who has conducted extensive research on vitamin D.In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Haridy R (28 February 2022). "One type of vitamin D found to boost immune system, another may hinder it". New Atlas . Retrieved 7 April 2022. Over 18% of the population exceeds the NIH daily recommended allowance ( RDA) of 600–800 IU, [2] by taking over 1000 IU, which suggests intentional supplement intake. [165] A deficiency of vitamin D can have serious consequences in the body. Vitamin D is vital for these reasons:

If you are taking the rapidly-dissolving tablets, dry your hands before handling the medication. Place each dose on the tongue, allow it to dissolve completely, and then swallow it with saliva or water. You do not need to take this medication with water. A review published in 2015 noted that adverse effects have been reported only at 25(OH)D serum concentrations above 200 nmol/L. [153] The dietary reference intake for vitamin D issued in 2010 by the Institute of Medicine (IoM) (renamed National Academy of Medicine in 2015), superseded previous recommendations which were expressed in terms of adequate intake. The recommendations were formed assuming the individual has no skin synthesis of vitamin D because of inadequate sun exposure. The reference intake for vitamin D refers to total intake from food, beverages and supplements, and assumes that calcium requirements are being met. [58] :5 The tolerable upper intake level (UL) [121] is defined as "the highest average daily intake of a nutrient that is likely to pose no risk of adverse health effects for nearly all persons in the general population." [58] :403 Although ULs are believed to be safe, information on the long-term effects is incomplete and these levels of intake are not recommended for long-term consumption. [58] :403 :433 Vitamin D supplementation in low doses (400 to 1000 IU/day) may slightly decrease the overall risk of acute respiratory tract infections. [86] The benefits were found in young children and adolescents (ages 1 up to 16 years) and were not confirmed with higher doses (>1000 IU per day or more). [86] Vitamin D supplementation substantially reduces the rate of moderate or severe exacerbations of COPD in people with baseline 25(OH)D levels under 25nmol/L, but not in those with less severe deficiency. [87] Asthma [ edit ] Vitamin D 2 was chemically characterized in 1931. In 1935, the chemical structure of vitamin D 3 was defined and shown to result from the ultraviolet irradiation of 7-dehydrocholesterol. A chemical nomenclature for vitamin D forms was recommended in 1981, [15] but alternative names remain in common use. [4]

The Role of Vitamin D3

For all forms of vitamin D (sunlight, food, and supplements), the recommended dosage is 4,000 IUs for people nine years of age or older. Without a blood test I would not recommend going higher than that. Side Effects of D3 Speaking with your doctor can help determine the right amount of vitamin D for you. Blood samples are needed to run a 25-hydroxy (or 25-OH) vitamin D test. This blood test is best way to determine how much Vitamin D is in your body. There are conflicting reports concerning the relative effectiveness of cholecalciferol (D 3) versus ergocalciferol (D 2), with some studies suggesting less efficacy of D 2, and others showing no difference. There are differences in absorption, binding and inactivation of the two forms, with evidence usually favoring cholecalciferol in raising levels in blood, although more research is needed. [23]

Vitamin D3 serves many purposes in the body, from strong bones to cancer protection. Below are the potential ways vitamin D3 can benefits your health: 1) Strong Bones a b "Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 11 February 2016. Archived from the original on 31 December 2016 . Retrieved 30 December 2016. Researchers have reported that the compound is less toxic to non-target species than earlier generations of anticoagulant rodenticides ( Warfarin and congeners) or Bromethalin, [52] and that relay toxicosis (poisoning by eating a poisoned animal) has not been documented. [15] Nevertheless, the same source reports that use of cholecalciferol in rodenticides may still pose a significant hazard to other animals, such as dogs and cats, when rodenticide bait or other forms of cholecalciferol are directly ingested. [15] See also [ edit ]Just 3 ounces of rainbow trout provides 645 IU for 81% of the DV. It is also rich in heart-healthy omega-3 fatty acids.

The EFSA reviewed safe levels of intake in 2012, [118] setting the tolerable upper limit for adults at 100 μg/day (4000 IU), a similar conclusion as the IOM. The conversion from ergosterol to vitamin D 2 follows a similar procedure, forming previtamin D 2 by photolysis, which isomerizes to vitamin D 2 ( ergocalciferol). [172] The transformation of previtamin D 2 to vitamin D 2 in methanol has a rate comparable to that of Chemically, the various forms of vitamin D are secosteroids, that is, steroids in which one of the bonds in the steroid rings is broken. [16] The structural difference between vitamin D 2 and vitamin D 3 is in the side chain, which contains a double bond, between carbons 22 and 23, and a methyl group on carbon 24 in vitamin D 2. [4] Many vitamin D analogues have been synthesized. [4] Biology [ edit ] Calcium regulation in the human body. [17] The role of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) is shown in orange. Low circulating vitamin D levels have been associated with lower total testosterone levels in males. Vitamin D supplementation could potentially improve total testosterone concentration, although more research is needed. [27] Other diseases [ edit ]Colecalciferol is a form of vitamin D. It helps your body to take in more calcium and phosphorous from the food you eat, and helps your kidneys to keep more calcium instead of peeing it out. Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, etal. (June 2012). "Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis". The American Journal of Clinical Nutrition. 95 (6): 1357–64. doi: 10.3945/ajcn.111.031070. PMC 3349454. PMID 22552031.