Purposes: [1] To assess the hypoallergenicity of Neocate with synbiotics in IgE-mediated cow milk allergy, [2] To evaluate growth outcomes and formula tolerance in healthy infants fed Neocate with synbiotics. Methodology: [1] Thirty infants & children with IgE-mediated cow milk allergy used Neocate with synbiotics followed by a double-blind, placebo-controlled food challenge. [2] Healthy infants (0-15 days) were randomly assigned to receive a control amino acid-based formula or Neocate with synbiotics for 16 weeks. (n=115) Results/Conclusion: [1] This study demonstrated that Neocate with synbiotics is safe, well-tolerated and hypoallergenic according to American Academy of Pediatrics guidelines. [2] This study demonstrated that Neocate with synbiotics is safe, well tolerated and promotes normal growth when fed to healthy infants. A list of publications that mention the study or use of Neocate, including links to publicly available abstracts and full-text articles, where available The daily intake of Complete Amino Acid Mix should be divided into equal portions and distributed throughout the day. Purpose: To evaluate growth outcomes and formula tolerance in infants with IgE- or non-IgE-mediated cow milk allergy fed Neocate with synbiotics. Methodology: Infants with CMA were randomly assigned to receive Neocate with synbiotics or a control formula (Neocate ® Infant DHA/ARA) for 16 weeks. (n=110) Results/Conclusion: This study demonstrated that Neocate with synbiotics is safe and promotes normal growth in infants with cow milk allergy.

Isolauri E, Sampson HA. Use of an amino acid based formula in the management of cow’s milk allergy and multiple food protein intolerance in children. J Allergy Clin Immunol. 2004;113:S154(518).Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Sunflower Oil, Canola Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, L-Tyrosine, Dipotassium Phosphate, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides (CITREM), Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D 3, Cyanocobalamin. A napi mennyiséget és a higítás mértékét orvosnak vagy dietetikusnak kell megállapítania, ez a mennyiség függ a beteg életkorától, a testsúlyától és egészségi állapotától. Javasolt koncentráció 21,1% w/v (1 kcal/ml) – 1 csapott adagolókanál por minden 30 ml vízhez. Egy csapott adagolókanállal 7,3 g por mérhető ki. Összemennyiség ml Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Sunflower Oil, Canola Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, Artificial Flavor, L-Tyrosine, Dipotassium Phosphate, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides (CITREM), Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Sucralose, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D 3, Cyanocobalamin. Corn Syrup Solids (51%), Refined Vegetable Oil (Medium Chain Triglycerides (8%), High Oleic Sunflower Oil (6%), Sunflower Oil (4%), Canola Oil (4%)), Fructooligosaccharides (Oligofructose (4%), Inulin (0.5%)), less than 2% of each of the following:Dipotassium Phosphate, Tricalcium Phosphate, Calcium Carbonate, Calcium Glycerophosphate, L-Arginine L-Aspartate, Calcium Phosphate Dibasic, L-Leucine, L-Lysine Acetate, Tripotassium Citrate, L-Glutamine, L-Proline, L-Valine, Citric Acid Esters of Mono- and Diglycerides (CITREM), Glycine, L-Isoleucine, L-Threonine, L-Phenylalanine, L-Tyrosine, L-Serine, L-Histidine, L-Alanine, Sodium Chloride, L-Cystine, L-Tryptophan, Magnesium Chloride, Choline Bitartrate, L-Methionine, Tricalcium Citrate, Magnesium L-Aspartate, M. alpina Oil*, C. cohnii Oil**, M-Inositol, L-Ascorbic Acid, Taurine, Ferrous Sulfate, Zinc Sulfate, L-Carnitine, Uridine 5’-Monophosphate Disodium Salt, Cytidine 5’-Monophosphate, Niacinamide, Inosine 5’-Monophosphate Disodium Salt, Adenosine 5’-Monophosphate, Calcium D-Pantothenate, Guanosine 5’-Monophosphate Disodium Salt, DL-alpha Tocopheryl Acetate, Bifidobacterium breve M-16V, Ascorbyl Palmitate, Manganese Sulfate, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Cupric Sulfate, Riboflavin, Vitamin A Acetate, DL-alpha Tocopherol, Potassium Iodide, Mixed Tocopherols, Folic Acid, Chromium Chloride, Phylloquinone, Sodium Selenite, Sodium Molybdate, D-Biotin, Vitamin D 3, Cyanocobalamin.

Make up 1/2 (50%) of the required amount of their usual formula, and the remaining 1/2 (50%) of the feed with Neocate Junior. Repeat this for each feed for three days. Classified as GREY non-formulary by the APC in July 2013 as they felt that there was not enough evidence to recommend this for prescribing.It contains a unique dual energy source of carbohydrate and fat (no protein, vitamins or minerals). Duocal ® is flavorless and is suitable for oral and tube feeding. Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Sunflower Oil, Canola Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, Artificial Flavor, L-Tyrosine, Dipotassium Phosphate, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides (CITREM), Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Citric Acid, Sunflower Lecithin, Sucralose, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D 3, Cyanocobalamin. A list of publications that mention the study or use of Neocate, including links to publicly available abstracts or full-text articles, when available Dosage should be determined by a healthcare professional and is dependent on the age, body weight, and medical condition of the patient. Not for parenteral use. Not suitable for use as a sole source of nutrition - must be given in conjunction with other sources of nutrition to supply the fluid and general nutrition requirements of the patient in quantities as prescribed by a clinician or dietitian. Grey / Non-Formulary (no formal assessment): APC has not formally reviewed this medicine or indication because it had never been requested for formulary inclusion. Often used for drugs new to market.

Must be used under medical supervision. Suitable as a sole source of nutrition from 1-10 years, or as a supplement to the diet from 1 year onwards. Serum levels of micronutrients, particularly phosphorus, should be routinely monitored by clinicians when Neocate is used as a primary or sole source of nutrition for patients with complex systemic disease involving diagnoses and intestinal disease, especially in combination with tube feeding and/or a history of prematurity.

Duocal ® offers ideal support for children who need extra calories that can support vibrant health and catch-up growth. Research around the world has shown how Neocate helps support normal growth and development in infants and children with cow milk allegy and related gastrointestinal (GI) conditions. The Neocate Formula Difference: its Amino Acid-Based