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There are no standard specifications when it comes to the recommended CFUs. Probiotic supplements tend to contain anywhere from one to 10 billion CFU per serving, with some up to 100 billion. Probiotics; ( L. rhamnosus, L. casei L. plantarum B. animalis) prebiotics (383 mg of fructooligosaccharides and 100 mg of galactooligosaccharides)
Some multi-strain probiotics showed enhanced benefits due to the constituent strains’ synergy and additive effects resulting in high adhesion to the mucosae and pathogen inhibition within the digestive tract [ 66]. The genetics of the constituent species or strains of multi-microbial probiotics is vital for understanding the mechanisms by which they interact with each other, the intestinal microbiota, and the host. A comparative genomic analysis of the multi-strain probiotics VSL#3 by Douillard, et al. [ 67] revealed numerous genes that encode various bioactive substances associated with the probiotics’ health benefits. These include genes involved in lactose transport ( lacF), peptidase activity, carbohydrate, metal, and amino acid transport. Some bacteria are endowed with extra-cellular structures known as fimbriae or pili that can adhere to the intestinal epithelium [ 68, 69]. Two main types of pili are found in LAB and Bifidobacteria; the tight adherence pili (Tad pili) and the sortase-dependent pili where genes were found in some isolates of VSL#3 probiotics [ 67]. The Tad pilus gene clusters of B. breve (one of the VSL#3) strains are highly conserved and involved in gut colonization in mice [ 69]. All the isolates in VSL#3 also encoded cell-surface proteins carrying LPXTG motifs that enhance interactions with the host cells [ 67]. Several genes that encode fibronectin-binding region proteins, collagen adhesins, outer membrane proteins, fimbriae or pili were also identified in L. helveticus BD08, L. plantarum BP06, L. acidophilus BA05 and B. animalis subsp. lactis BL03 and BI04 with possible roles in host adherence [ 70]. Lactobacillus plantarum BP06 was shown to harbor the sortase-substrate, which were also present in L. plantarum WCFS1 in addition to a large mucus-binding protein that is O-glycosylated by N-acetyl-hexosamine [ 71]. These peptides are secreted in a glycosylated form and may have a host signaling function [ 72]. The presence of the genes encoding Tad pili, sortase-dependent pili, mucus binding proteins, some even glycosylated, and S-layer proteins involved in the interactions of probiotic isolates with one another, the host cells and the host’s microbiota showed that the combination of different species and strains might offer possible complementary, additive and synergistic effects in the gut [ 67]. Experimental assessment of the effects of single-strain probiotics of L. helveticus R0052, B. longum subsp. infantis R0033, and B. bifidum R0071 and the multi-strain preparation of all the three isolates revealed that the multi-strain synergistically influenced both T-helper type 1 (T H1) and T-helper type 2 (T H2) responses in Wistar rat models infected with enterotoxigenic Escherichia coli (ETEC) and Nippostrongylus brasiliensis, respectively [ 73]. The mechanism by which the multi-strain probiotics exerts their effects was proposed to be through the downregulation of the nuclear factor-kappa-B (NFκB) pathway [ 74].
Thorne also claims the proprietary blend of Lactobacillus gasseri, Bifidobacterium longum, and Bifidobacterium bifidum may support gut and immune health.
An imbalance in your gut microbiome is believed to contribute to a number of health problems — and not just gastrointestinal issues, but immune dysfunction and infections as well. The microbe balance can be disrupted by diet, emotional and physical stress, and use of antibiotics, which destroy the good bacteria along with the bad. Medina M, Izquierdo E, Ennahar S, et al. Differential immunomodulatory properties of Bifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. 2007;150:531–538. The best probiotics can do wonders for the body by supporting a healthy immune system, digestive health, and vaginal health. But most importantly, we believe NOW Probiotic-10™ lives up to its marketing claims. After two weeks taking this supplement, our tester found their IBS symptoms had visibly reduced, and they experienced a marked improvement to their digestion. They also reported feeling ‘lighter’ and less lethargic.https://www.researchgate.net/profile/Endeshaw-Abatenh/publication/326010124_health-benefits-of-probiotics/links/5b334e3ba6fdcc8506d16506/health-benefits-of-probiotics.pdf
Some strains perform completely different tasks. The top products will have complimentary strains that perform a myriad of different tasks.In an older 2014 study, researchers gave females and males with obesity Lactobacillus rhamnosus. The results suggested that females lost weight and fat during the trial and maintained the loss after study completion. The males in the study, however, did not. The methods of evaluating probiotics are controversial and many still believe these products can be judged by the number of colony-forming units (CFUs).
It is vegan, third-party tested, and certified by the Clean Label project. It is free from most major allergens, including wheat, gluten, soy, milk, egg, fish, shellfish, and peanuts. It does not contain artificial colors, flavors, or preservatives. What’s more, Symprove is also enriched with vitamin C and prebiotic germinated barley. According to the Journal of Gastroenterology, germinated barley contains compounds that may help with inflammatory diseases like ulcerative colitis. Symprove supplements are also vegan-friendly and free from gluten and dairy.Probiotics are sold as supplements, which means they’re not regulated by the U.S. Food and Drug Administration (FDA). This means companies can essentially throw whatever they want into a supplement and call it a probiotic. To keep yourself safe and make sure you’re getting the probiotics you really want, you’ll need to keep a keen eye on the labeling and read up on scientific studies and research reports to determine which probiotics have made positive outcomes on specific conditions. You’ll also want to pay close attention to the expiration date, as colony-forming units tend to decline over time rendering them less helpful. For conditions such as Crohn’s disease, ulcerative colitis, IBS, and acute infectious gastroenteritis, probiotics are only recommended in the context of a clinical trial. A 2019 review of obesity and probiotics concluded that mixtures of probiotic strains may be more effective in treating obesity than single strains. In particular, Bifidobacterium may be effective for reducing body mass index (BMI).
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