Imidazole derivatives such as oxymetazoline are readily absorbed across mucosal membranes, especially in children. In adult subjects with erythema associated with rosacea, the mean ± standard deviation (SD) C max was 60.5 ± 53.9 pg/mL and the AUC from time 0 to 24 hours (AUC 0-24hr) was 895 ±798 pg x hr/mL following topical administration of first-dose oxymetazoline. Following once-daily topical applications for 28 days, the mean ± SD C max was 66.4 ± 67.1 pg/mL and the AUC 0-24hr was 1050 ± 992 pg x hr/mL. Following twice-daily applications for 28 days, the mean ± SD C max was 68.8 ± 61.1 pg/mL and the AUC 0-24hr was 1530 ± 922 pg x hr/mL.

Ans : This syrup should be used on the basis of severity of symptoms or as consulted by the doctor. There are some advised dose for the children of 2 to 6 years of age is 2.5 - 5 ml every hours and 5 - 10 ml every hour for the children above 6 years of age. And all the doses should be given in a proper measured manner with a measuring cup. For the best results it should be given at evenly spaced intervals.

It is not habit-forming in most case but it can get addictive for some. You may consult a doctor if you are experiencing signs of addictiveness. Maxtra is an adrenergic α1- and α2-agonist and a direct-acting sympathomimetic drug. By stimulating adrenergic receptors, oxymetazoline causes vasoconstriction of dilated arterioles and reduces blood flow. In a radioligand competition study, oxymetazoline displayed higher affinity at α1A-adrenoceptors compared to α2B-adrenoceptors, but with higher potency at α2B-adrenoceptors. When sprayed intranasally, oxymetazoline relieved relief nasal congestion and improved nasal airflow in patients with acute coryzal rhinitis for up to 12 hours following a single dose. The syrup does interact with certain medicines or ingredients that can result in negative implications. If you are under medications or supplements that have ingredients or drugs like alcohol, antipsychotics, digoxin, decongestants, phenytoin, sedatives or tricyclic antidepressants. You must consult a doctor to get a better understanding on how to go about the dosages or look for substitutes in such conditions. Maxtra binds to α 1- and α 2-adrenoceptors, which are Gq-protein-coupled receptors that promote vascular smooth muscle contraction by increasing intracellular calcium levels in response to ligand activation.

You should avoid driving whenever possible if you are under this medication. It may cause drowsiness or dizziness in some cases, which can affect your driving skills.

Below is the list of medicines, which have the same composition, strength and form as Maxtra Syrup , and hence can be used as its substitute.